Food Safety Authority issues new statement on BPA

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7/23/2008-The European Food Safety Authorityís (EFSA) AFC Panel today issued a further scientific opinion on a specific aspect of the chemical bisphenol A (BPA).

EFSA Statement:

The conclusions of the Panel are that after exposure to BPA the human body rapidly metabolises and eliminates the substance. This represents an important metabolic difference compared with rats.

The Panel concluded that the exposure of the human featus would be negligible because the mother rapidly metabolises and eliminates BPA from her body.

The scientists also concluded that newborns are similarly able to metabolise and eliminate BPA at doses below 1 milligram per kilogram of body weight per day. This implies that newborns could effectively clear BPA at levels far in excess of the TDI of 0.05 mg/kg bw set by the Panel and therefore its 2006 risk assessment remains valid.

The Panel considered the significant differences between humans and rodents, such as the fact that people metabolise and excrete BPA far more quickly than rodents. This body of evidence further limits the relevance of low-dose effects of BPA reported in some rodent studies used for human risk assessment.

EFSA took note of the U.S. National Toxicology Programís draft brief on BPA and of the Canadian governmentís recent Draft Screening Assessment on BPA, which took into account findings from the low-dose studies, notably with respect to neurodevelopmental toxicity, though both pointed out that these studies were limited in rigour, consistency and biological plausibility.


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