Non-E. coli O157:H7 Serotypes linked to Hemolytic Uremic Syndrome (HUS)

Source of Article:

I was reading recently an article in the European Journal of Clinical Microbiology & Infectious Diseases by R. J. Pomajz, M. Varman, A. Holst and A. Chen entitled, Hemolytic uremic syndrome (HUS) incidence and etiologies at a regional Children’s Hospital in 2001–2006. Here is the abstract:

Hemolytic uremic syndrome (HUS) is a serious health concern in children. HUS has primarily been linked to Escherichia coli O157:H7 infections, but non-O157 strains are gaining attention. Hemolytic anemia, thrombocytopenia, and acute renal failure are the characteristics of the syndrome. This study investigated the incidence of HUS at a regional Children’s Hospital between 2001 and 2006 by retrospective review. Cases of HUS were investigated for outcomes based on stool culture and an association of acute pancreatitis. A total of 44 cases were identified, of which 57% were female and 43% were male, with an age distribution of 13 months to 17 years and a median age of 3.44 years. Data revealed 13 cases in 2006 compared to two cases in 2001, with 84% of all illnesses occurring in the summer and fall seasons. The median duration of thrombocytopenia was eight days and 50% of all cases required dialysis. E. coli O157:H7 was the predominant pathogen; however, 53% of the cases had unknown etiology. This data may suggest a growing number of cases from 2001 to 2006 and a role for agents other than E. coli O157:H7. E. coli O157:H7 caused longer intensive care unit (ICU) stay. No association between HUS and acute pancreatitis was found.

In addition, the article itself noted: “An increasing number of reports show E. coli of the non-O157 serotypes as the causative agent in developing HUS. Some non-O157 serotypes that have been associated with HUS include O26, O103, O111” and others.

Posted on August 18, 2009 by E. coli Lawyer



Main Page

setstats            Copyright (C) All rights reserved under

            If you have any comments, please  send your email to