Optimer drug treats traveler's diarrhea: study
Published: Tuesday, October 28, 2008
Source of Article: http://www.canada.com/topics/travel/story.html?id=55950858-e685-4d16-88ff-2e210c2b321b
Tests of Optimer Pharmaceuticals Inc drug prulifloxacin show it stopped the cramps and diarrhea of so-called Montezuma's Revenge within about a day.
One benefit of the drug over older antibiotics is that it can be taken
just once a day, Dr. Herbert DuPont of the University of
has few side-effects and might even be used to prevent diarrhea, which
affects up to 40 percent of the 100 million people who visit Latin America, Africa
"The drug could be used prophylactically and I would anticipate it would be highly efficacious," he said.
DuPont tested travelers returning to the
In those who could be tested for infection, 71 percent were well within 48 hours after getting prulifloxacin, compared to 33 percent of those given a placebo pill, he said.
Dr. Sherwood Gorbach of Optimer
said the drug is approved to treat urinary tract infection in
DuPont noted that several drugs are available to treat traveler's diarrhea, but they either do not affect such a wide range of bacteria, the bacteria has evolved resistance to the drugs, or people do not take the pills properly.
Comparable drugs include ciprofloxacin, doxycyclene and ampicillin, but prulifloxacin only needs to be taken once a day for three days.
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