Volume
14, Number 12–December 2008
Dispatch
Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion
Protein
Source of Article: http://www.cdc.gov/eid/content/14/12/1898.htm
Vincent Béringue,  Laëtitia Herzog, Fabienne Reine, Annick Le Dur, Cristina Casalone,
Jean-Luc Vilotte, and Hubert Laude
Author affiliations: Institut National de la Recherche Agronomique, Jouy-en-Josas, France (V. Béringue,
L. Herzog, F. Reine, A. Le Dur,
J.-L. Vilotte, H. Laude); and Istituto
Zooprofilattico Sperimentale
del Piemonte, Liguria
e Valle d'Aosta, Turin, Italy
(C. Casalone)
Suggested
citation for this article
Abstract
To assess risk for cattle-to-human transmission of prions
that cause uncommon forms of bovine spongiform encephalopathy (BSE), we
inoculated mice expressing human PrP Met129
with field isolates. Unlike classical BSE agent, L-type prions
appeared to propagate in these mice with no obvious transmission barrier.
H-type prions failed to infect the mice.
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